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The BM of vascular SMCs in the media were characterized by a strong expression of collXVIII and a patchy expression of perlecan (Figure 2A and B).
Consistent with the patchy expression of Fgf8 in only some topographic OHCs we found a patchy aberration of stereocilia where some 'OHCs' had stereocilia twice as thick as others, resembling the diameter of inner hair cell stereocilia (Fig. 8M,N).
Fzd3 was found to be strictly confined to the spinous layer in the epidermis and was the only receptor exhibiting a non-homogeneous patchy expression pattern such that strongly positive cells are intersperced with Fzd3-negative cells in a mosaic-like pattern.
Immunofluorescence staining with the antibody directed against N-terminal domains of LMα1 chain demonstrated patchy expression of truncated LMα1 chain in basement membranes of skeletal and cardiac muscle, and in endoneurium and perineurium of sciatic nerve of δE3 transgenic mice (Figure S1).
Patchy expression throughout the epidermis has also been reported [ 26].
Immunohistochemistry showed patchy expression of chromogranin A (CgA) and synaptophysin (Syn).
Similar(33)
According to their suggestion, patchy CK7 expression with variable involvement of deep glands was seen in incomplete gastric intestinal metaplasia, whereas strong CK20 expression in superficial and deep glands with the absence of CK7 expression was seen in complete gastric intestinal metaplasia.
Close analysis of the accessory lobe further illustrated the presence of single progenitor cells in the distal mesenchyme of the CKO lung (Fig 6b',a' arrowhead) and patchy LacZ expression around the bronchi compared to WT lungs (Fig. 6b',c' arrows).
These phenotypes were observed in restricted regions in which patchy EGFP expression was observed.
Using immunocytochemistry, Gomez-Sanchez et al. [83] found patchy low expression of H6PDH in the brain that was not fully congruent with 11β-HSD1.
2a) Discontinuous MTJs: The authors show that Paxillin does not localize to MTJs at 20hpf, there is patchy laminin expression, and Fak phosphorylation is disrupted.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com