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Within four weeks Genzyme returns 12 million cultured cells to the surgeon, who injects them under a thin patch of membrane taken from a healthy section of the patient's upper shin bone.
In the 66 negative experiments, it was unclear whether ET had failed to produce an effect (may be no ET receptor was present in the recorded patch of membrane or the pore/channel activation occurred during the process of sealing of the patch pipette to the plasma membrane of granule cell).
Gentle suction was then applied to draw a patch of membrane into the pipette tip.
In all cases, the Enzyme IIBC species were restricted to a small patch of membrane while the glycolytic metabolons were positioned 4 nm away.
What happens when enzymes responsible for import are restricted to a patch of membrane or when cytoplasmic enzymes are bound to membrane enzymes or transporters?
Simulating what is currently considered a large patch of membrane has hence enabled us to study the process of spinodal decomposition in more detail than we would have otherwise been able to.
Similar(51)
In cells stained with the Rosetteless antibody, we see three main areas of immunofluorescence: (1) an extracellular meshwork in the center of rosettes, (2) in single cells and chains, a thin patch of membrane-associated staining that is most often found at the base of cells but sometimes seen in other parts of the cell, and (3) faint staining throughout the cell body in single cells and rosettes.
Sure enough, patches of membrane tissue were detected along the bone supports.
Harder T, Scheiffele P, Verkade P, Simons K. Lipid domain structure of the plasma membrane revealed by patching of membrane components.
cGMP opens cation-selective channels when applied to the cytoplasmic side of excised patches of membrane from retinal rod outer segments (ROS).
With gentle retraction it was possible to obtain large patches of membrane engulfing the nucleus of the neuron.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com