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Future study will address whether its use concurrently or in sequence with other highly effective agents, such as enzalutamide or sipuleucel-T, will result in synergistic effects, and whether, as is currently done with leuprolide acetate, abiraterone acetate should be continued past progression.
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In the past, tonotopic progressions have often been demonstrated by following the trajectory of a single activation peak as a function of frequency or by comparing response profiles along a chosen curve across the cortical surface.
Eduardo's stoppage-time goal earned Shakhtar Donetsk a 1-0 second-leg win to round off a comfortable progression past Anderlecht, 4-1 on aggregate.
The season began with progression past League One Bournemouth in the Capital One Cup, and victory against Plymouth here means three wins from their opening three league games, the first time Oxford have opened a Football League season with a trio of victories for 18 years.
Furthermore, the activation of some, but not all, nutrient signaling pathways may lead to uncoupling of events required for budding from progression past Start.
This result was striking given that progression past PIN was only seen at 42 52 wks post-OHT when Pten excisions were triggered at 6 wks of age.
Interestingly, we did not observe progression past high grade PIN lesions until mice had been aged for almost a year post-OHT administration (Figure 4).
There was no additional progression past PIN lesions in 4 experimental animals when these were aged to 30 40 wks p.i., however, the PIN lesions became more prominent, and showed a wider area of distribution within the prostate (data not shown).
Progression past Start in G1 and entry into S phase require the activity of the Cdc28 cyclin-dependent kinase, which is regulated by the G1 cyclin Cln3 upstream of the cyclins Cln1 and Cln2 (reviewed in [55]).
Fertilization activates the anaphase-promoting complex/cyclosome (APC/C), triggering progression past anaphase I [ 3].
Progression past meiosis metaphase I requires activation of the APC/C.
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