In the past, production linkage systems have been limited by their inability to handle increasingly large datasets.
This gene has been proposed as a candidate gene for autism susceptibility in the past, although linkage and association studies have been inconsistent [Cook Jr et al., 1998; Guffanti et al., 2011; Nurmi et al., 2001].
An alternative possibility to multiple separate mutational events being responsible for these apparently unconnected P102L IPD kindreds is that these small pedigrees do share a common ancestor with the large pedigree but that this was long enough in the past for linkage to the disease haplotype to have broken down.
Why did the strongest Muslim political reform movements in the contemporary Middle East emerge in Iran and Turkey, which substantially differ from each other in terms of political rule, religious establishment, socioeconomic structure, cultural past, and international linkages?
Microsatellite used mostly in the past as markers for linkage studies in polygenic diseases should be revisited, as they may have disempowered the linkage strategy.
As the "Sage of Quincy Massachusettss)," Adams resembled an American version of Edmund Burke, which meant that he attributed the success of the American Revolution to its linkage with past practices, most especially the tradition of representative government established in the colonial assemblies.
Our finding that the Avr3c gene of P. sojae lies in close proximity to the Avr4/6 gene substantiates past studies describing genetic linkage of these avirulence determinants [22].
The association between the DAT SNP rs27072 and NS, which did not survive significance after correction for multiple comparisons (FDR p-value = 0.137), also has a linkage to past research.
For the past 20 years, genetic linkage combined with positional cloning has achieved tremendous success for mapping the variations that underlie monogenic Mendelian diseases (Jimenez-Sanchez et al. 2001).
In today's digital environment, the linkages between past and present work are more readily laid bare.
