Exact(1)
After taking baseline measurements and eligibility screening within 56 days after the start of the past exacerbation, informed consent is obtained and stratified block randomisation will take place.
Similar(59)
Among patients with chronic obstructive pulmonary disease (COPD), the frequency and severity of past exacerbations potentiates future events.
The strong correlation between bacterial eradication at EOT and continued clinical cure up to 8 weeks past the exacerbation emphasises the importance of antibiotic treatment in AECOPD.
Exacerbation risk is assessed according to GOLD category for forced expiratory volume in 1 second (FEV1) and past history of exacerbations, while symptoms burden is assessed by the modified Medical Research Council (mMRC) dyspnea grading scale and/or the COPD Assessment Test (CAT), based on the worst case scenario.
Additionally, an elevated PA/A has been associated with past and future exacerbations in patients with moderate-to-severe COPD.
Subjects were free of significant chronic disease (other than COPD) that might put them at risk during bronchoscopy (e.g. known congestive heart failure, MI in past year, history of pneumonia in the past 6 months, or bronchitis/COPD exacerbation within the past month) and recruited from the community by word of mouth and written advertisements.
Concurrent menopausal symptoms as well as history of mood exacerbation during past reproductive events were assessed.
Such studies also indicate that, in the past, the burden of exacerbations of asthma among children whose asthma was caused by living near roadways might have been significantly underestimated (Perez et al., 2012).
An earlier study from the USA 14 (which was given a weak global rating) recruited 199 children with asthma of whom 53 lived with only one adult who smoked and 30 lived with two adults who smoked; the risk for an exacerbation over the past 12 months was 1.8 (95% CI 1.4 to 2.2) for those living with two compared with one adult who smoked.
Risk factors for death from asthma are [ 1]: 1. Past history of sudden severe exacerbations.
· have had at least 2 hospitalisations or clinical exacerbations over the past 2 years due to suspected poor adherence.
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