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Victory Aircraft recovered its momentum and went on to become one of Howe's greatest industrial successes, producing Avro aircraft under licence, including the Lancaster, and developing the passenger variant, the Avro Lancastrian.
After basic design work was completed on the Tu-4 bomber Tupolev decided to design a passenger variant with a pressurized fuselage given the internal designation of Tu-70.
The Tupolev Tu-70 (NATO reporting name: Cart) was a Soviet passenger variant of the Tu-4 bomber (which was a reverse-engineered copy of the American-made Boeing B-29 Superfortress) designed immediately after the end of World War II.
A role in splicing was confirmed for all except that in tumour 1072, which is therefore regarded as a passenger variant.
Users have the option to use their own estimates of passenger variant frequencies or to select from a library of pre-computed passenger frequency tables for several common cancers.
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Potential sources of such "passenger variants" in the edited lines are addressed below (see Discussion).
Whole-genome sequencing of five edited strains revealed the presence of passenger variants, but no mutations at predicted off-target sites.
These specific genes might be non-relevant passenger variants, and might decrease in number with the progressive incorporation of new large-scale tumour resequencing data.
No plausible effect was identified for intronic variants in tumours 1473 and 500 or cell line U-BLC1, so these variants were regarded as passenger variants and not considered further.
However, it is challenging to distinguish true cancer-associated mutations from a large amount of "passenger" variants detected in these studies that are likely to be irrelevant to cancer progression.
Toyota still does not intend to bring the seven-passenger variant to North America.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com