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Despite their similarities in the protein structure and cellular localization at chromosome passenger complex, AurkC displayed unique characteristics different from AurkB.
Survivin is an integral component of chromosomal passenger complex (CPC) where it binds to borealin and INCENP through its dimerization interface.
Interestingly, it was recently revealed that Plk3 interacts with members of the chromosomal passenger complex [44].
Aurora B kinase is a key component of the chromosomal passenger complex (CPC), which regulates chromosome segregation and cytokinesis.
Cdca8 encodes a member of the centromeric chromosomal passenger complex (CPC) required for correct alignment and segregation of chromosomes [35].
Survivin is a unique member of the IAP family and has an intriguing function in the chromosomal passenger complex (CPC).
The mechanism leading to furrow regression remains unclear as several likely candidate proteins, those of the chromosomal passenger complex, appear to function normally in megakaryocytes [42], [43].
In human cells, Mps1 promotes biorientation by regulating Aurora B activity through phosphorylation of the chromosomal passenger complex (CPC) member Borealin [12], [14].
This directs survivin to the centromere and regulates the assembly of the chromosomal passenger complex.
Heterochromatin is thought to facilitate recruitment of the chromosome passenger complex (CPC).
The chromosomal passenger complex (CPC) generates spindle assembly in the absence of a RanGTP gradient [ 5, 6].
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