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Even though a bill finally passed, the need to get three Republican Senators to vote yes on it led to a reduction of $80bn in the final package, retarding the extent to which the program helped the economy.
As time passed, the need of the Khmer Rouge for the support of Prince Sihanouk lessened.
Meanwhile, as the threat of invasion passed the need for large armoured formations had lessened, and the divisions had been broken up between mid-1943 and 1944 with only one operational brigade remaining by the end of the war.
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Pre-activation of T cells by IL-15, which by-passes the need for CD25, renders T cells resistant to suppression by MM tumour cells.
Herein, we present a way to by-pass the need for developing multiple clones of antibodies against HER-2, but rather we use HBsAg, which serves as a lightning rod for attracting all the clones of antibodies generated by immunization.
I suspect it will probably have something to do with tapping directly into the brain and by passing the need to draw at all.
Since lymphopenia is induced by irradiation in our model, activation of the cross-presenting APCs could by-pass the need for CD40 engagement by CD4+ T helpers.
We were therefore interested in learning if expression of one of the Notch targets, Hes1, could by-pass the need for mutations of Notch receptors.
Overexpression of growth factors and, growth factor receptors will make aromatase overexpressing cells able to by-pass the need of estradiol for proliferation.
No significant difference was seen in the rates of double-strand break repair (DSBR) between the two cell types, but DSBR in mammospheres appears to by-pass the need for H2AX phosphorylation.
Aging by itself is a selective force that favors cancer probably because aging cells are signal resistant, thus providing selective advantage to cells that by-pass the need in mitogenic signals.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com