Serial in vitro passaging of pathogenic bacteria and viruses is a classical method for obtaining attenuated strains that can be used either as vaccines or as safe laboratory model strains to study basic functions of the pathogen [1].
A live vaccine strain (LVS) was developed in the former Soviet Union from multiple passages of the less pathogenic type B biovar, and remains the only available vaccine shown to offer significant protection against virulent F. tularensis strains.
Considering the patency of lacrimal passage and the location of the lesion, hydrodynamic factors may lead to the deposition of pathogenic microorganisms near the angle of the canaliculus.
Normally, your body has defenses against the incursion of pathogenic bacteria, but this method could result in the defeat of those defenses, making your nasal passages more susceptible to infection.
For example, water disinfection requires deactivation of pathogenic organisms.
Our ancestors had no inkling of the role of pathogenic micro-organisms in transmitting disease.
These methods also have limited power to prioritize pathogenic ncSNVs when the proportion of pathogenic relative to non-pathogenic ncSNVs in a candidate list is small.
Supplementary Figure 10 The distribution of pathogenic variants.
Self-propagation of pathogenic protein aggregates in neurodegenerative diseases.
In fact, they often protect us from disease because they compete with, and thus limit the proliferation of, pathogenic bacteria.
