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Blood vessels exhibit highly regulated barrier function allowing selective passage of macromolecules.
In epithelial cells, the ECM combines the use of a highly organized collagen network, hyaluronic acid, and a number of proteins to prohibit the passage of macromolecules through tissue.
Our approach to rational design was to combine the properties of a pH-independent peptide, MelP5, which forms large pores allowing passage of macromolecules, with the properties of two pH-dependent membrane-active peptides, pHlip and GALA.
This study suggests that ETX alters small intestinal homeostasis and allow the paracellular passage of macromolecules as it was previously observed [9].
The basement membrane, which consists of laminin, fibronectin, collagens, and proteoglycans [8], [9], separates adjacent tissues, acting as a barrier to the passage of macromolecules and cell migration.
Removal of the glycocalyx increases vascular protein permeability, providing evidence that it hinders the passage of macromolecules [ 35, 36].
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As a transporter, it must allow small molecules to pass as freely, prevent most macromolecules from crossing, and permit the quickest possible passage of selected macromolecules bidirectionally across the NE.
Instead, the presence of NTRs slowed down the passive NPC passage of inert macromolecules.
Several mesoscale models have attempted to explain how FG Nups prevent the passage of most macromolecules while allowing selective transport of TFs alone and with their cargo.
Endothelial cells of the microvasculature represent a critical site of barrier regulation, selectively permitting passage of fluid, macromolecules, and cells into the extravascular tissue.
Vascular endothelium plays a critical role as a sophisticated gate-keeper that regulates the passage of solutes, macromolecules and circulating cells across the blood vessel wall [ 1].
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