Sentence examples for pass clearance from inspiring English sources

In humans, the two predominant carboxylesterases CES1 and CES2 are abundantly expressed in liver and intestine, respectively (Jones et al., 2013; Williams et al., 2010), the two organs that are responsible for first pass clearance of xenobiotics, but also the organs that are most active in lipoprotein secretion.

As hypothesized, the ipsilateral fetuses were exposed to significantly more hyperglycemia than contralateral fetuses, with substantive first pass clearance of glucose into the ipsilateral placentae and fetuses.

Consequently, in order to achieve a dose which would be clinically useful, we would need to by-pass this first pass clearance of the liver.

As a consequence, most of the drugs are rapidly cleared from the blood and display high first pass clearances by the liver.

Measurement of insulin levels in the portal vein showed a time window of absorption that was consistent with systemic concentration-time profiles and approximately 50% first-pass clearance by the liver.

Passing clearance was also significantly greater than landing clearance (p < 0.001).

There was a significant effect of step number on landing and passing clearance (p = 0.01, p < 0.001 respectively).

Clearance was divided into landing and passing clearance depending on the planned placement of the foot in relation to the step edge being cleared.

"This seems like an unreasonably long period of time to post, or give access to, something that has already passed clearance".

Coadministered drugs like allopurinol and methotrexate also affect the first-pass clearance and metabolism of 6-MP.

Extensive intestinal and hepatic conjugation of silybin A and silybin B followed by rapid elimination likely would limit the interaction potential to first-pass clearance of sensitive substrates.