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Initially shown to boost oxidative metabolism in diet-induced models of obesity, Parp1 ablation or inhibition has recently been reported to remarkably rescue pharmacological models of liver cirrhosis, partly by correcting the associated mitochondrial impairment (Mukhopadhyay et al., 2013).
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Administration of histone deacetylase (HDAC) inhibitors such as suberoylanilide hydroxamic acid (SAHA) have consistently shown therapeutic potential in models of HD, at least partly through increasing the association of acetylated histones with down-regulated genes and by correcting mRNA abnormalities.
Then they got into deeper trouble by only partly correcting the problem -- they mailed corrected ballots primarily to Mr. Goodman's strongest area.
I think this argument is partly, but only partly, correct.
By knowing the biologically functional genomic windows of these motifs a priori, motifs that did not occur in biologically functional genomic windows were excluded, partly correcting for spurious matches.
It is generally held that administrative ills can be at least partly corrected by reorganization.
(There is, however, a small problem in retrieving some of the information: the bibliographic system in the printed text simply lists references in order of appearance, making it difficult to check whether a particular author or article has been cited. This problem is partly corrected by the online referencing system, which can be found at http://shapiro.bsd.uchicago.edu/evolution21.shtml).shtml
Three months after Brando died of pulmonary fibrosis at age 80, some of the people closest to the actor, who was known for protecting his privacy, have begun to speak publicly about his life, partly to correct the notion, fostered by tabloid stories, that he died a recluse, almost penniless and deeply in debt.
This limitation is partly corrected for by adding NOMESKO Classification of Surgical Procedures surgical codes to the inclusion criteria.
These defects may theoretically be partly corrected pharmacologically by a rapid-acting insulin analog before meals, mimicking the lacking postprandial insulin peak; by an insulin sensitizer improving peripheral insulin action; and by metformin reducing hepatic glucose production (1).
Partly to correct their distortions, the distinguished British chemist J. R. Partington (1886 1965) undertook to study the origins of gunpowder.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com