We found that when the OR coding sequence is partitioned broadly into transmembrane domains (TMs) 1 7 and non-transmembrane domains (excluding the N- and C-terminal tails), none of these regions exhibits positive selection.
The cut point defining younger versus older age at exposure was chosen to broadly partition the ages at which exposures occur; there was minimal impact on relative rate estimates of selecting alternative cut points of 40 years or 50 years (results not shown).
Variation partitioning has been broadly applied in ecological and evolutionary studies [ 19].
Fatty acids within hepatocytes are broadly partitioned between esterification and oxidation pathways (23).
A survey of genes in the 22 altered regions revealed that they could be broadly partitioned into three major functional categories: RTK/RAS signalling (FGFR2, KRAS, ERBB2, EGFR, MET); transcriptional regulation (MYC, GATA4, GATA6, KLF5) and cell cycle control (CCND1, CCNE1, CDK6, CDKN2A/B, RB).
Broadly speaking, our formulation partitions the exposure characteristics into clusters and links these to the disease response in a unified Bayesian model that we refer to as profile regression [ 10].
Although the Procrustes ANOVAs and the PCAs both produce broadly similar results, these analyses differ substantially in how they partition the total variation into components.
Insofar as it broadly combines first and second codon positions, and separates out third codon positions, this partitioning scheme is similar to a popular traditional partitioning method that does the same [ 75].
These approaches can be broadly catagorized as algorithms that project linear and nonlinear covariance structures (97, 106), hierarchical and partitioning clustering algorithms (107, 108) and network trajectory algorithms (109).
