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Particularly well characterized are its roles as a co-stimulatory signal for T cell stimulation [18] and in mediating neutrophil adhesion and migration through endothelial cell monolayers [19] [21].
Of course, A53T-SNCA overexpression would affect neural function also outside the nigrostriatal projection, but this model system is particularly well characterized and these mice were specifically generated and characterized with regard to the transgene presence in the substantia nigra and striatum.
Specific HDAC inhibitor (HDACi) drugs have been particularly well characterized.
Among the Rho GTPases, Cdc42, RhoA and Rac-1 are particularly well characterized.
Some genes involved in the initiation of trichome development have been particularly well characterized in Arabidopsis.
Three principal arms of the UPR have been identified and are particularly well characterized in mammals.
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Plasma membrane and cytosolic hexosaminidase is not well characterized, particularly as regards their isoenzyme forms and their relationship with the lysosomal ones.
The molecular processes underlying extinction and the mechanisms which determine if memory will reconsolidate or extinguish after retrieval are not well characterized, particularly the role of transcription factors and gene expression.
As a result, insect stress responses within plant-insect systems are less well characterized, particularly at the molecular level.
For this study, we selected the transcription factor GR as the client protein because it is well characterized, particularly with respect to its associations with the Hsp90/Hsp70 systems (Sanchez, 2012).
The most common histologic subtypes of RCC, clear cell, papillary, and chromophobe have distinct genetic and clinical characteristics; however, epidemiologic features of these subtypes have not been well characterized, particularly regarding any associations between race, disease subtypes, and recent incidence trends.
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