There are an estimated 390,900 different species of plants known to science, and new species are continually being described, particularly from previously unexplored tropical areas of the world.
The detonation failure process, specifically where a transient reaction occurs in an overdriven explosive due to a sub-critical charge diameter, has remained relatively unexplored, particularly regarding its relationship to shock initiation mechanisms.
The value of adaptive clinical trial methods in exploratory phase (phase 2) clinical research is generally well accepted, but the potential value and challenges of applying adaptive clinical trial methods in large confirmatory phase clinical trials are relatively unexplored, particularly in the academic setting.
While the role of decreased BMD has been explored, that of injury, particularly falls, remains unexplored and requires elucidation.
But the molecular players and the complex mechanisms involved remain largely unexplored, particularly in human and other metazoans.
Another particularly interesting and unexplored area is the link between redox homeostasis and drug efficacy.
The relationship between reliability, validity, responsiveness and discrimination is largely unexplored, particularly for longitudinal measurements.
Without such training and expansion of the user community, the science and policy potential of increasingly available data will go unexplored, particularly in the developing world the geographic areas of greatest biodiversity and environmental concern.
Nodal signalling is an absolute requirement for normal mesoderm and endoderm formation in vertebrate embryos, yet the transcriptional networks acting directly downstream of Nodal and the extent to which they are conserved is largely unexplored, particularly in vivo.
The intriguing role of Exonic Splicing Enhancer and Silencer (ESE and ESS, respectively), sequences that substantially contribute to alternative splicing by regulating the splice site selection, is still largely unexplored, particularly when the proper exon inclusion is mandatory to encode a functional protein.
