The risks of a long-term hormonal treatment initiated very early in life remain however undefined particularly in children who have an increased risk of secondary neoplasia.
Moreover, the specific contribution of HIF-1α in regulating TICs in breast cancer remains undefined, particularly in the context of syngeneic rodent models that recapitulate the breast cancer microenvironment.
The risk of further immunosuppression from PDT, particularly in OTRs, is however undefined due to limited investigations to date.
The scope and extent of initial staging work-up and follow-up, especially with respect to distant disease, is undefined and deserves further evaluation, particularly given the increasing recognition of the prevalence of distant disease.
Secondly, the pathological correlate of WM abnormalities, particularly at early stages, remain largely undefined.
The scenes in which a bleary-eyed Lowell tries to ingratiate himself with his foreign colleagues (the work they do is undefined) are smart and funny, particularly when Ms. Washburn spoofs the kind of condescending anti-Americanism that Yanks abroad must choose to swallow or contentiously challenge.
The molecular mechanism by which B. sphaericus binary toxin Bin kills mosquito larvae, particularly from the genera Culex and Anopheles is still undefined [3].
This is particularly advantageous if industrial waste feedstock, containing compounds of undefined composition, are used [ 21].
Childhood cerebellar ataxias, and particularly congenital ataxias, are heterogeneous disorders and several remain undefined.
However, this novel reaction, and particularly the postulated enzyme(s) and gene(s) involved, remained undefined.
