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Headaches are a common medical problem, yet few studies, particularly trials, have evaluated therapies that might prevent or control headaches.
The incidence of cardiovascular disease in many trials used to inform the assumptions for our modelling, particularly trials on lipid lowering, 44 is substantially higher than the risk in our study.
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Trials, particularly capital trials, with a very lengthy appellate process, are a considerable expense for taxpayers to endure even once.
In particularly long trials, the BOLD response in a region might cumulate over the interval between trials and carry over to the scans chosen as a baseline for the successive trial.
New canine models of DMD with different mutations would therefore significantly compliment research, particularly therapeutic trials.
Additional studies, particularly clinical trials, are needed.
Moreover, access to innovative therapies, particularly clinical trials, is also essential in the fight against this disease.
Therefore, further research, particularly clinical trials, needs to be conducted regarding this issue before any recommendations can be made.
The study was further limited to recruitment to biomedical research (and particularly clinical trials) in an acute hospital setting, rather than to health research in general.
Future research, particularly interventional trials, is required if we are effectively to understand, prevent, and treat the negative sequelae of critical illness.
Finally, careful consideration must be given to age and genotype when conducting future treatment-oriented research with DCA, particularly cancer trials involving adults.
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