Sentence examples for particularly problematic issue from inspiring English sources

One particularly problematic issue is that short accession numbers may be identical to medically important terms, such as "CD-34".

Tissue sampling can be a particularly problematic issue in IBC, since most cases present with no discrete mass and therefore accurate targeting of the area of breast for image-guided CNBs can be difficult [ 5, 6].

Another particularly problematic management issue was contact with the review process for those research projects that needed ethical clearance (points 2.7 and 2.9).

This is particularly a problematic issue when assessing CRC progression and when comparing adenoma to cancer tissue.

The banana in the opening scene was colored incorrectly, as the Korean animators were unfamiliar with the fruit, and the final bathtub scene was particularly problematic, including issues with lip sync.

Any other particularly tough issue?

They found it particularly problematic when PCC issues were raised at the end of a consultation for another issue.

These issues are particularly problematic in recent GWAS because the number of polymorphisms can reach millions, but the number of phenotyped and genotyped individuals is rarely more than hundreds of thousands.

Among Mr. Bloomberg's targets are some of the Senate's most vulnerable Democrats, including Kay R. Hagan of North Carolina, Mary L. Landrieu of Louisiana and Mark L. Pryor of Arkansas, for whom the gun issue is particularly problematic because they will need Republican votes to win re-election.

This issue is particularly problematic for 'trailing spouses' whose common property assets are usually held under multiple jurisdictions, and/or off-shore accounts.

The latter issue is particularly problematic for researchers studying mechanisms of evolution of reproductive isolation between populations in sympatry [ 21].