In its first three years, as well as demonstrating that two parties could govern together, it rewired the NHS, turned most English secondary schools into academies, and announced a rolling back of public expenditure, most particularly of benefits for the poor, which defied all historical precedent.
The differences in KRAS mutation rates identified suggest that sex and tumor location influence the chance of clinical usefulness of EGFR inhibitors with a particularly low likelihood of benefit among female rectal cancer patients.
Furthermore, the short time of breath-hold reduces the problem of respiratory motion artifacts, which is of particularly benefit in patients of more advanced age (such as CABG patients) who may be unable to perform extended breath-holds.
Endovascular treatment (EVAR) of abdominal aortic aneurysm (AAA) is thought to be of benefit, particularly in patients aged ≥80 years.
Treatment of tumor cells engineered to secrete or display chaperones may be of benefit, particularly in the area of cell-based vaccine development.
There is an emphasis on monitoring of side-effects if episodic parent-initiated high-dose ICS or oral corticosteroids are prescribed, particularly given the lack of benefit seen with the latter.
A greater understanding of current feeding practices, including the use of feeding protocols, and the influence of nutrition support on recovery would be of benefit, particularly as head-injured patients are likely to stay in hospital for significant periods of time, allowing nutrition to influence outcomes.
For example, the use of very high levels of tidal volume which cause lung injury may suggest that the dopamine instillation strategy could be of benefit, particularly in patients who cannot tolerate low tidal volume, as is the case for a small proportion of patients who require ventilation with injuriously high tidal volumes.
It was widely hoped 13 that the recently updated review of the evidence by Marmot et al 14 would put an end to the controversy, but disagreements between experts about breast screening persist, particularly around the amount of benefit and the risk of overdiagnosis.
A high probability of early stopping for lack-of-benefit is particularly desirable given the disease rarity and contrast between trial arms.
