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In the pancreas, a local RAS is present, with the expression and localization of angiotensinogen and AT1 receptors particularly localized in the islets and endothelial cells of the pancreatic vasculature (16).
Children with autism had a significant reduction in total GM volume, particularly localized within fronto-striatal and parietal networks [15].
NAA is found at relatively high concentrations in the human central nervous system and is particularly localized within neurons and related to neuronal processes [4], [6].
The composition of subunits in nAChRs determines ligand specificity, ligand affinity, cation permeability, and channel kinetics [ 2]. nAChR formed by α1, β1, γ, δ and ε subunits are called the muscle type of nAChR that is particularly localized in the skeletal motor unit.
These genes are highlighted in Figure 2. Iron metabolism is important for many reasons: there are many iron catalyzed oxygen reactions that can damage cells; there are many sources of iron, particularly localized in the human lung; and iron-related genes are often coordinately regulated with oxidative stress defenses in E. coli [ 32].
FGFR2 has two different isoforms that are designated FGFR2 IIIb and FGFR2 IIIc; the former is particularly localized in epithelial cells with growth induced by FGF-1, 3, 7, 10 and the latter binds FGF-1, 2, 4, 6, 9 and is expressed mainly in mesenchymal cells [ 25, 26].
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CR is expressed in neurones of the rat dorsal horn, particularly those localized to laminae II, and more intensely within laminae V and VI (Ren and Ruda 1994).
7– 9 The degree of visible depigmentation in vitiligo, particularly when localized to the face, head and neck, and genitalia, correlates with psychological impact.
BN-PAGE (Blue native PAGE) has become a major technique in the analysis of multiprotein complexes, particularly those localized to membranes [ 15].
The table highlights the well-known perturbation of oxidative phosphorylation and energetics in insulin resistant states, particularly changes localized in mitochondria.
In mammals, DNA methylation has traditionally been associated with gene repression, particularly when localized to promoter regions (Bird and Wolffe 1999; Weber et al. 2007; Suzuki and Bird 2008).
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