A particularly strong indication for a late neofunctionalization event comes from the expression and selection pattern of the rac1a A and B copies, which are specific to the cichlid lineage (note that rac1a also has been duplicated in the medaka, but according to our phylogenetic reconstruction, this is an independent event).
These data can be further stratified by indication (antibiotic starts for UTI, respiratory tract infection, skin and soft tissue infection), particularly if the indications for the antibiotic are routinely included on prescriber orders (see above).
This lack of knowledge about antiemetics is particularly important considering the restricted indications for their use in Italy (this is particularly true for metoclopramide).
He also defined indications for retinotomy, particularly when proliferative vitreoretinopathy (PVR) is responsible for circumferential/axial retinal traction [ 2].
For this reason, some health technology assessment agencies 6 do not consider PFS a patient-relevant outcome measurement and usually discard the information on this end point in their evaluations, particularly in indications and for investigational compounds where PFS may not be a well-established surrogate for OS.
Companies sometimes seek initial FDA approval for two indications, particularly for antimicrobials.
The latter sign and endoscopically occult haemorrhage represent indications for transarterial embolisation, particularly in patients unfit for surgical reintervention [4, 29].
Conclusions: Policies varied, particularly regarding prophylactic ART for women without indications for treatment and did not always follow current European guidelines.
Indications for medical procedures are particularly challenging to derive from administrative health data because of the lack of indication codes, and, therefore, require automated data algorithms [ 5- 7].
This study has shown that respiratory diseases are common indications for admissions of children in Enugu particularly among those under five years of age.
