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The main function of DNMT1 is to ensure the propagation of existing methylation patterns, whilst DNMT3A and DNMT3B are primarily required for de novo methylation, with DNMT3L acting as an essential cofactor, particularly in the establishment of methylation imprints in the gametes [18] [22].
Clearly, we still have much to learn about the varied mechanisms by which DNA methylation can contribute to the regulation of gene expression, particularly in the establishment of tissue-specific expression during development.
The strength of sheep as a model for the human lies in the fact that time courses of fetal and perinatal development are comparable, particularly in the establishment of hypothalamic neural networks and the rapid growth of adipose tissue during late gestation (32).
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She was particularly active in the establishment of a woman's college (later named for her) in Rio de Janeiro and of the Woman's Christian Medical College in Shanghai.
But the number of machines grew exponentially in the 1980s, particularly with the establishment of ATM networks that enabled the instant transfer of funds within and between banks.
Moreover, they illustrate a unique opportunity to use the gene knock-down constructs in primary endometrial cells in order to study their biological roles in the porcine endometrium, particularly during the establishment of pregnancy.
These findings are relevant for global organisations that are designing or implementing similar service evaluations, particularly as the establishment of more call centres in developing countries is likely with increased access to and decreased cost of telecommunications services.
Translation rights have become a valuable source of additional revenue, particularly since the establishment of the Berne Convention.
Further research into paramedics' management of women in labour is recommended, particularly the establishment of a minimum dataset.
In the 13th century the university gained added strength, particularly in theology, with the establishment of several religious orders, principally Dominicans and Franciscans, in the town of Oxford.
This makes it particularly appropriate for the establishment of sub-national to national reference levels in tropical regions with reduced satellite image quality and technical resources.
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