Sentence examples for particularly in exon from inspiring English sources

KRAS mutations, particularly in exon 2, were identified as a predictive marker of resistance in patients with mCRC, 10– 13 and practice guidelines issued by the European Society for Medical Oncology stressed that EGFR-targeted mAbs should not be used in patients with tumors harboring such mutations.

GISTs with KIT mutation, particularly in exon 11, show a clearly better response to imatinib therapy as compared to tumours with no mutation, suggesting that detection of gain-of-function mutation and not solely KIT expression should be a requirement for the treatment (Heinrich et al, 2003).

A similar pattern of binding sites was seen for H3K4me3 and RNA Pol II in the two cell lines, particularly in exons (range 2.7-3.1 2.7-3.1anslated regions (range 2.8-4.0%) and introns (41.2-41.4% for RNA Pol II and 49.2-51.9% for H3K4me3).

Moreover, the sequences are highly conserved particularly in the exons, with identity percentages varying between 98 and 100%.

These clues provide a framework for elucidating mechanisms involved in the organization of eukaryotic genomes and particularly in building exon-intron structures.

All these patterns of exon-intron variation revealed by our investigation provide a framework for elucidating mechanisms involved in the organization of eukaryotic genomes and particularly in building exon-intron structures.

The full 394 bp EVADR lncRNA gene demonstrated high sequence identity in apes and OWMs, particularly in the exons, with the introns showing decreasing identity with increasing phylogenetic distance.

MRS were particularly rare in exons, which contained less than half the MRS expected.

Particularly, extensive deletions in exon 2 and intron 2 and altered protein structure (4nAT and 2nF1) (Supplementary Figure S9) indicate marked sequence change as a consequence of hybridization.

Nevertheless, the gene is highly variable, particularly in the largest exon outside the functional motif, while other regions appear to be under strong positive selection.

This is particularly important as mutations in exon four in causing anti-mitotic drug resistance are less demonstrated when compared to exon 1, 2 and 3.