The management of Barrett's esophagus (BE), particularly high grade dysplasia (HGD), is an area of much debate and controversy.
It should be noted that the quality of the Swedish Cancer Registry in reporting of CNS tumours, particularly high grade glioma, has been seriously questioned [ 20, 21].
The high expression of HER-2/ neu and COX-2 in DCIS (particularly high grade) combined with the clear correlation between proliferation and COX-2 expression in DCIS (Boland et al, 2004) has stimulated interest in the use of COX-2 inhibitors to prevent recurrent DCIS in ER-positive and -negative disease.
Previously, we have found STAT3 to be activated in meningiomas, particularly higher grade tumors.
But "a just-unveiled symbolic action suggests, however, that something even more nefarious is afoot". Lefty bloggers insisted that the logo meant nothing of the sort, suggesting the right-wingers must have found some particularly high-grade hallucinogens.
We reported that human 15-LO-1 (designated as leukocyte type 12-LO or 12/15-LO 12/15-LO) in expressed in humouserostate and iscrexpressedPCa, partinularly humangrade prostate
We have shown that aberrant overexpression of 15-LO-1 occurs in human PCa, particularly high-grade PCa, and in high-grade prostatic intraepithelial neoplasia (HGPIN), and that the murine orthologue is increased in SV40-based genetically engineered mouse (GEM) models of PCa, such as LADY and TRansgenic Adenocarcinoma of Mouse Prostate.
The tumor suppressors p53 and PTEN are commonly mutated in human neoplasms including glial tumors, particularly high-grade astrocytomas and secondary glioblastomas.
It has been proposed that detecting in situ cancer, particularly high-grade DCIS, would prevent the development of high-grade invasive cancer (Lampejo et al., 1994; Evans et al., 1997, 2001).
The high frequency of mutations in these cancers, particularly in high grade disease, suggests that functional inactivation of this pathway may be an obligate event.
In summary, a considerable body of evidence indicates that DCIS, particularly of high grade, shares many molecular genetic alterations with invasive carcinoma [ 4- 8, 14, 15].
