Extracellular adenosine represents an endogenous distress signal, particularly generated under injurious conditions such as hypoxia or ischemia [21], [22].
The cytoplasmic CO2 is particularly generated by the mitochondrial metabolism [ 31].
It is noteworthy that the superoxide anion productions (1,2- and 2,3-enolization of the Schiff's base and oxidation of the enolate anion) are particularly generated from early glycation products [ 19, 20].
For example, unlike traditional mobile traffic which is dominant in downlink rather than in uplink, M2M is an uplink-dominant traffic which particularly generates bursty traffic volumes.
Interestingly, PGC-1α direct down-regulation by RNAi results in the downregulation of SOD2 and other antioxidant enzymes, and particularly generates a lack of their induction after exposure to stressors such as H2O2, markedly resembling the situation in frataxin-deficient cells [46].
However, this contrasts dramatically with the large proportion of non-synonymous mutations, particularly generating frameshifts and stop codons, within the exons, indicating strong selection against this function.
Some sustainability advocates however are not optimistic about the role of voluntary standards, particularly those generated within the industry itself.
Now, Pfizer is seeking to avoid paying the taxes that are due on its profits, particularly profits generated by its overseas subsidiaries.
Populist religious movements, particularly those generated by Amidist beliefs during the Heian period, grew even stronger and more diverse during the Kamakura period, increasing demands for Buddhist iconography.
Those assignments, particularly Lehman, generated hundreds of millions of dollars in fees, not only in bankruptcy work, but also from the reams of litigation that flowed from them.
In her recent article "We need to value foster care, not fixate on adoption", Judith Rees raises some important issues about current policy and particularly those generated by Clause 1 of the children and families bill.
