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Mortality remains high, particularly for candidaemia (40.0 %).
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By applying this approach to candidaemia, we identified novel susceptibility genes and pathways for candidaemia, and future studies should assess their potential as therapeutic targets.
We identify three novel genetic risk factors for candidaemia, which we subsequently validate for their role in antifungal host defence.
Based on the intersection of transcriptome pathways and genomic data, we prioritized 31 candidate genes for candidaemia susceptibility.
Therefore, we have applied an integrative genomics approach to identify novel susceptibility genes and pathways for candidaemia.
However, the surgical origin of ICU patients was already identified as a factor of good prognosis for candidaemia [31].
Individuals carrying two or more risk alleles have an increased risk for candidaemia of 19.4-fold compared with individuals carrying no risk allele.
In our study, we observed a day-28 mortality rate set at 40, 25.7, and 25.4 % for candidaemia, deep-seated IC, and cIAI, respectively.
Regarding ESCMID guidelines, the compliance with the following recommendations was evaluated: a preferred use of echinocandin, the removal of any CVC in case of candidaemia (if not possible, echinocandin or liposomal amphotericin B use is recommended), and de-escalation to be considered after 10 days of treatment for candidaemia.
Echinocandins are recommended first-line treatment for candidaemia [ 1].
The candidaemia rate of 4.5% in the placebo arm of this meta-analysis is consistent with the estimated risk of candidaemia in patients with at least one risk factor for candidaemia.
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