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Such patients are particularly difficult to ascertain, and an objective measure of the VA will provide an important contribution to the evaluation of such cases.
Both case-control and case-only study designs are feasible, with the latter adding flexibility and reducing the need for a large control sample size, which can be particularly difficult to ascertain in admixed populations.
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Grasslands are one of the more difficult areas to classify as managed or unmanaged because human intervention, particularly livestock grazing, can be difficult to ascertain from satellite remote sensing data.
It will be worthwhile in future studies to specifically evaluate the extent to which this "48-hour increase" criterion leads to differences in AKI diagnoses and study conclusions in pediatric populations, particularly since this criterion is often difficult to ascertain.
However, the poor preservation of the P. spinodorsalis specimens, particularly of the appendages on the head, make it difficult to ascertain its taxonomic placement.
Sample size in qualitative research is difficult to ascertain and specify in advance, particularly in ethnographic designs where multiple sources of data are appropriate in gaining important insights.
That's particularly true if the patient is deceased—"It's difficult to ascertain a cause of death when you don't have a core body temperature," notes George Luber, associate director for climate change at the CDC.
"Storms Frank and Eva were particularly hard on Scotland in particular and it is still difficult to ascertain what the full financial impact of the storms and the rainfall from this will be," said PwC's general insurance leader Mohammad Khan.
Finally, with reference to Lepore et al.'s study, the exact point of clinical and radiographic fracture union is clearly difficult to ascertain with any reliability or reproducibility, particularly since patient follow-up was on a 2 monthly basis.
Despite this, ophthalmologists often found it difficult to ascertain when it is appropriate to certify patients, particularly for people with long-term conditions.
The potential functional meaning of the positive selection in eutherian mammal ABAD/HSD10 proteins, particularly in the regions belonging to the substrate binding cleft is, however, difficult to ascertain given the enzyme multiple substrate specificities and participation in various metabolic pathways.
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