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While Jim Parsons has won four Emmy awards for his portrayal of Sheldon Cooper, the show itself is not particularly critically acclaimed.
Therapy with ribavirin has proven beneficial in certain patient populations, particularly critically ill patients on mechanical ventilation and lung transplant recipients.
Detection of MBL and ESBL producing Gram-negative bacilli especially P. aeruginosa is crucial for optimal treatment of patients particularly critically ill and hospitalized patients and to control the spread of resistance.
Limiting the use and types of antibiotics, particularly "critically important antimicrobials" [ Food and Agriculture Organization of the United Nations/World Organization for Animal Health/World Health Organization (FAO/OIE/WHO) 2004; WHO 2012a], in animal production is the most direct route of controlling agricultural antibiotic release into the environment, and likely also antibiotic resistance.
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However, diagnosing infection is very important, particularly in critically ill.
Indeed, the distribution of extravascular water among different body compartments differs from patient to patient, particularly in critically ill patients with varying degrees of capillary leak.
However, clinical studies on biomarkers are still scarce, particularly in critically ill patients, and sensitivity and specificity of individual biomarkers remain unacceptably low [48].
Bronchoscopy and bronchoalveolar lavage (BAL) are common procedures in intensive care units; however, no contemporaneous safety and outcomes data have been reported, particularly for critically ill patients.
Early diagnosing of pneumonia is very important to promptly starting the treatment; otherwise, it can be life-threatening or associated with high morbidity particularly in critically ill patients who need immediate decision.
This is one of the few recent studies to evaluate the relative ability of the two dosing approaches in the prevention of resistance; similar studies, particularly involving critically ill patients, should ensue.
Purpose: The diagnosis of pulmonary infiltrates often requires CT scanning since clinical data can be unreliable, particularly in critically ill and immunosuppressed patients, and bedside chest radiography (CXR) can be misleading.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com