In particular, the tolerability issues associated with these approaches will require careful evaluation in order to demonstrate whether it may be safer to use a combination of highly targeted agents, or one multitargeted drug.
It may have particular utility where tolerability is an issue, and may have particular benefit in patients with mood-associated or negative symptoms.
Two adjuvant trials were initiated to compare efficacy and in particular long-term tolerability and safety in early breast cancer patients.
More recently, a generalized index of exchangeability based on a meta-analysis of empirical data has been suggested as a means of estimating the tolerability of particular amino acid exchanges [10].
9 Stahl outlines three potential benefits of SPARI medications: 1) faster onset of action, 2) greater efficacy, and 3) better tolerability, in particular lower sexual side effects.
In particular, it has a tolerability profile characteristics of NSAIDs, with gastrointestinal disturbances (pain, dyspepsia, nausea, and vomiting) being the most remarkable events.
16 53–55 These analyses confirm the efficacy of DPP-4 inhibitors, in terms of HbA1c reduction, and their tolerability, in particular resulting from the absence of weight gain and low risk of hypoglycaemia associated with monotherapy.
Efficacy and safety/tolerability profiles for T2DM treatment options are considered in selecting the therapy best-suited to a patient and their particular comorbidities and tolerances [ 16].
Of particular relevance is the GI tolerability of the various formulations, as bisphosphonates in general have the potential to cause GI irritation and implications may exist for individualizing treatment.
As mentioned earlier, owing to concerns regarding fluoxetine tolerability in this particular group of adolescents, the dose of fluoxetine used in this study was limited to 20 mg/day.
