The discovery of the NFATc1+ proliferative tubule population is consistent with the notion that nephrons contain a particular subset of cells that divide after injury.
These results suggest that FGF-2 in vitro selects for the survival of a particular subset of cells enriched in pluripotent mesenchymal precursors and is useful in obtaining a large number of cells with preserved differentiation potential for mesenchymal tissue repair.
First described by Emmert-Buck et al. in 1996, laser capture microdissection is a powerful and precise technique used to study protein changes in a particular subset of cells in a low-maintenance system that is easy to operate [ 8].
Importantly, an agent with such a large range of targets is unlikely to exert its effect specifically on a particular subset of cells, such as cancer cells, thereby suggesting to re-evaluate the potential of siramesine and its analogues as drugs, and of sigma-2 receptors as targets, in anticancer therapy.
As Ly6Chigh monocytes appear to be the main precursors of plaque macrophages (Swirski et al., 2007), it is likely that the ability of aspirin to decrease atherosclerosis progression is primarily due to its negative modulatory action on arterial accumulation of this particular subset of cells.
For example, a particular subset of cell bodies can be visualized by retrograde labeling with fluorescent dextran, a method that has been widely used to analyze the morphologies of retinal ganglion cells that project to defined retinorecipient areas in the brain [e.g. ref. 2].
As resistance to ABT-737 depends only on signal 1 activation, antigen-specific T cells can be further influenced by ILs to generate particular subsets of T cells in vitro, such as donor-reactive regulatory T cells or CMV-reactive cytotoxic T cells.
High doses of epratuzumab may affect a specific function of B cells, a particular subset of B cells, the trafficking of B cells into different anatomical compartments and/or induce alternative signalling events not seen at lower doses.
The heterogeneity of clinical responses might reasonably be explained by the random manipulation of the immune system being determined by mathematical probability when chemotherapeutic regimens are randomly applied without consideration of which particular subsets of susceptible immunological cells are actively proliferating at the time of each dosing.
Cancer stem cells, which are a particular subset of cancer cells responsible for tumorigenesis, chemoresistance and metastasis, are emerging targets in cancer research [ 9].
