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Each country will choose based on a patient's needs and the availability and suitability of a particular regimen.
Will a more personalized, more definitive risk assessment improve a patient's willingness to adhere to a particular regimen?
Well-designed large prospective trials are needed to identify key genes among the multiple potential candidates that can help a clinician make real-time treatment decisions in respect to a particular regimen depending on a patient's pharmacogenetic profile.
In conclusion, consideration should be given to the use of CR rate as a phase II endpoint to determine if a particular regimen should be compared to the standard in a phase III setting for extensive-stage SCLC.
An oncologist decides the choice of a particular regimen; however, modifications to drug dose and schedule are often necessary because of variabilities in the health of an individual patient.
Because of the small number of patients with retinoblastoma and the diversity of the disease characteristics in individual patients, there have been no clinical trials to determine whether to recommend a particular regimen, or to identify specific criteria in patients who would benefit from chemotherapy.
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It is in this setting that pharmacogenetic advances have the potential to play an important role in achieving superior clinical outcome among different subsets of patients through prospective prediction of clinical benefit to particular regimens.
Risk for CSDIs was not associated with particular regimens, although only 116 (11.6%) patients were receiving WHO second line regimens.
The role of future trials in neoadjuvant chemotherapy should continue to assess particular regimens based on individual patient demographics and tumor specifics.
Regardless, similar to the current need in neoadjuvant chemotherapy clinical research for MIBC, more head-to-head phase III adjuvant chemotherapy trials are necessary to understand the benefits and drawbacks of particular regimens with the hopes of offering a certain combination based on patient and tumor specifics.
As alluded to, the capability to determine tumour responsiveness to a particular chemotherapeutic regimen in a timely manner would be highly preferable, enabling superior tailoring of a NACT regimen with the objective of achieving a full pathological response.
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