Conceptual and experimental genetic approaches aimed at dissecting the molecular features of susceptibility genes, in particular those predisposing to cancer, are outlined and discussed in this reveiw.
"Does the geometry of a particular vessel predispose someone to arterial disease, for example?
Biological anti-rheumatic drugs in particular may predispose to wound infections (Konttinen et al. 2005).
Identifying disease associated rare variants, however, is challenging, because a particular rare disease predisposing allele may be present in only a handful of patients.
In addition, retinoic acid may be beneficial for the primary prevention of lung cancer in never-smokers with high risk factors, such as particular genetic mutations predisposing them to cancer development and for the secondary prevention of disease progression in never-smokers with premalignant lesions.
A calculation combining all lines of evidence can estimate the posterior probability that a particular gene variant is predisposing to disease.
In further support of this, we found that isolates harbouring genes for sialylation of LOS were significantly more likely to be isolated from patients with significant underlying diseases, presumably predisposing these particular patients to severe infections.
»How can we show that a particular CNV can predispose to specific traits…« How can we show that a particular CNV can predispose to specific traits when no clear clinical manifestation is visible?
We have studied HMEF performance under wet conditions to see which particular design features predispose to this complication.
It plans to cull these variations to find patterns of particular mutations that predispose patients to major killers such as heart failure, as well as genetic alterations that increase the risk of side effects from prescription drugs.
