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This special group seems to have particular psychological and practical difficulties, due to the peculiarities of their learning difficulties [ 48]; this with combination with anxiety, stress and academic failure, may probably led to academic and social isolation [ 49].
RCTs, however, are typically used to test single interventions, such as the benefits of a drug compared to placebo and although the principles underlying the testing of a more complex intervention are the same, particular theoretical and practical difficulties arise for researchers conducting trials and for clinicians attempting to critically appraise their results.
None of this is to gloss over the many practical difficulties that are likely to arise when constructing a particular gene drive in a given species.
In particular, after the MI intervention some participants appeared to have made concerted effort to overcome practical difficulties such as their child falling asleep before night-time brushing.
Their new technique, called picosecond imaging circuit analysis (PICA), involves capturing individual pulses of light using an ultrafast detector, so that the switching of particular gates can be recorded and then replayed (in slow motion) for analysis.PICA still has a few practical difficulties to overcome.
But practical difficulties endure.
There have been practical difficulties.
There are practical difficulties, too.
There are also big practical difficulties.
Then there are the practical difficulties.
It also throws up practical difficulties.
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CEO of Professional Science Editing for Scientists @ prosciediting.com