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A particular pattern of gene expression in cells exposed to a potential new drug molecule, for example, might give an indication that the molecule would ultimately be toxic in humans.
The O111 H8 cluster was visibly distinct from the rest, reiterating its particular pattern of gene content conservation across all 4,800 genes.
After transient exposure to stress, bistability allows some cells to maintain a particular pattern of gene expression long after the stimulus has ended.
The different tools therefore hold great promise for exposure assessment given the accumulating evidence that a given exposure can leave traces of its occurrence in terms of a particular pattern of gene expression, proteins or metabolites, although little is yet known about the duration of such alterations, the dose-response or the influence of confounding factors, for example [ 5].
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For instance, of the duplicate genes retained, there is a particular pattern of retention of genes that encode protein products associated with the extracellular matrices that are essential for skeletal development (Huxley-Jones et al. 2007) and of genes implicated in neural crest patterning and differentiation (Martinez-Morales et al. 2007).
It is important to realize that a particular pattern of expression of these genes, not just the genes themselves, predicts outcome.
In this paper we combine these two observations and suggest that TEs, besides rewiring the network, also played a central role in the evolution of particular patterns of combinatorial gene regulation.
However, we have shown that the particular pattern of gappiness found in alignments of partial gene sequences needs to be handled with care in order to obtain accurate phylogenies.
The 1051 smokers who started smoking at 16 years of age or younger were 1.5 times more likely to have a worse nicotine addiction if they had a particular pattern of six single-base changes in the genes than were those with other genetic patterns.
Such footprints should be studied at the level of functional subclasses of CNSs, such as those which flank genes with a particular pattern of expression.
AT-rich motif enrichment in 5' upstream sequences in A. gambiae, Ae. aegypti and the Drosophila genus immunity genes suggests a particular pattern of nucleosome formation/chromatin organization.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com