Sentence examples for particular mutation of the from inspiring English sources

In particular, mutation of the conserved Ala623 in third intracellular loop was reported to result in loss of TSH-stimulated IP formation leaving cAMP accumulation unaltered [16].

A fluorophores brightness will depend in detail on numerous factors, such as the fluorophore's local environment [37], [38], the excitation intensity [39], and the particular mutation of the molecular complex [21].

The location of osteosarcomas in long tubular bones and the axial skeleton was not significantly associated with a particular mutation of the TGFBR1*6A genotype.

Although resistance can be attained through many mechanisms, for infectious diseases and cancer, in particular, mutation of the direct target is often the source of resistance and is associated with accelerated mutation rates.

Most studies try to predict the relevance of a particular mutation on the basis of co-segregation in breast cancer families, the location in a functional domain or interference with the splicing machinery [ 42].

Therefore, the effect of p53 on balancing cellular ROS in cancer cells probably depends not only on the presence or absence of p53 but also on the particular mutation of p53, which might alter the preference of p53 for the regulation of distinct target genes [100].

Development of such indicators is requisite for making objective statements regarding the effects of interventions, or of particular mutations, on the deceleration (or acceleration) of aging.

In particular mutations of GJB1, the gene which encodes connexin 32 (Cx32), have been implicated in some forms of the X linked Charcot Marie Tooth (CMTX) disease, an inherited sensory and motor neuropathy [8].

"Or what it is". Scientists can also examine the role in virulence and transmission of particular mutations on the virus's genes.

An updated data concerning contribution of particular mutation to the resistance will demand only adjusting the threshold in software for determination of this mutation on a chip, without redesigning the microarray and PCR primer system.

In particular, mutations of p53 are the common feature of anaplastic thyroid cancer (Fagin et al, 1993).