Without loss of generality, let us assume that one distribution is for the gene expression level of a particular gene in normal tissues (i.e. subscript n), and that the other distribution is for cancerous tissues (i.e. subscript c).
In particular in the normal brain, ABC transporters are expressed in capillary endothelial cells where they protect neural tissue from blood-derived molecules thereby contributing to a functional blood brain barrier (Schinkel, 1999).
Cystatin C has been shown to be superior to serum creatinine as an estimate of GFR in several different patient populations, in particular, in the near-normal, normal and higher range, where creatinine-derived measures perform poorly [ 30].
For assessing its overall pharmacokinetic profiles in general and its ability to cross the blood-brain barrier (BBB) in particular, biodistribution studies in normal mice were performed.
39 was cleared by urinary excretion and was not retained in any particular organ, neither in normal nor in Rosa-26 mice, suggesting that 39 is not able to cross the cell membrane.
Therefore, damage can be expected in particular in rapidly dividing normal cells, like bone marrow, gastrointestinal mucosa and hair follicles, resulting in the most common side effects of chemotherapy like myelosuppression (decreased production of blood cells), mucositis (inflammation of the lining of the digestive tract) and alopecia (hair loss).
Sfrp2 encodes a secreted protein that acts as a modulator of the Wnt signalling pathway, in particular during normal skeletal patterning in developing limbs [ 78].
At P0, fine foot processes were embedded in the glomerular basement membrane, and in particular, normal slit diaphragms were formed between the foot processes.
In particular, normal hydration was not completely restored in 50% of calves with an enophthalmos of ≥ 7 mm on admission.
Continuous glucose monitoring (CGM) is suggested to increase practicalities and safety of insulin titration in ICU patients [ 1, 4], in particular when targeting normal or near-normal blood glucose levels when hypoglycemic episodes can be expected [ 5- 13].
