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Levi, barred too, now came to work for her in secret, their roles reversed.First there, and later in a safer house in the countryside (where she would cycle round from farm to farm, collecting the necessary eggs), the pair worked on the problem she made her own: how nerves growing out from an embryonic spinal cord find the particular developing limbs they will innervate.
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Sfrp2 encodes a secreted protein that acts as a modulator of the Wnt signalling pathway, in particular during normal skeletal patterning in developing limbs [ 78].
Some scientists argued that thalidomide damaged nerves in developing limbs.
Maini, P. K. & Solursh, M. Cellular mechanisms of pattern formation in the developing limb.
Kawakami, Y. et al. BMP signaling during bone pattern determination in the developing limb.
There are several BMPs expressed in the developing limb, including most importantly BMP2, BMP4, and BMP765.
Repeated removal of developing limb buds permanently reduces appendage size in the highly-regenerative axolotl.
Zhu, J. et al. Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud.
Nohno, T. et al. A chicken homeobox gene related to drosophila paired is predominantly expressed in the developing limb.
C. loss or disruption of signaling from the Ventral Ectoderm in the developing limb.
D. duplication of the Zone of Polarizing Activity in the developing limb.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com