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In contrast, alphavirus replicon particles target DCs [82] and feature viral molecular patterns with intrinsic adjuvant effects [53], [83].
Each session consisted of nasal exposure to combustion particles (target concentration of 1.0 mg/m3) or clean air for 1 hr, followed 3 hr later by challenge with whole pollen grains or placebo.
By addition of dextran-coated magnetic particles, target cells get magnetically tagged and remain in the tube when this is placed into the purple EasySep™ magnet while unwanted cells are poured off.
We found that a molar excess of 1000 free RGD peptides was able to prevent the molecular interaction between RGD-PVX particles and HT-29 cells, confirming that the RGD-PVX particles target integrins expressed on the surface of these cells (Fig. 7b).
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Seven focused ion beam sections were extracted from both Itokawa particles, targeting one splash melt and ten adhering particles to investigate their composition and provenance and the role of micrometeoroid impacts on Itokawa's surface.
They extracted seven focused ion beam sections from both of these Itokawa particles, targeting one splash melt and ten adhering particles, to investigate their composition and provenance and the role of micrometeoroid impacts on Itokawa's surface.
In the work reported here, investigation into the biology of this receptor using electron microscopy has demonstrated that iron oxide particles targeted to TfR are internalized and accumulate in lysosomal vesicles within cells.
Short-hairpin knockdown of AR was conducted using MISSIONTM lentiviral shRNA transduction particles targeting either the AR alone or a non-silencing shRNA control (Sigma-Aldrich, St . Louis MO).
29 These two counteracting forces will affect the particles' targeting and attachment abilities within the microvasculature.
In studies with particles targeted to inflamed vasculature using ICAM-1 and P-selectin, greater binding was achieved with dually targeted particles relative to particles targeted to P-selectin or ICAM-1 alone.
In contrast, our data show that phage particles targeting the DEC-205 receptor are able to trigger signaling in DCs.
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