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Chemist Masatake Haruta of Tokyo Metropolitan University in Japan agrees, saying that the next step is to better understand how gold particles activate the oxygen.
Moreover, it has been reported that CCM particles activate the inflammasome (Caicedo et al. 2009) thus triggering the release of proinflammatory mediators.
In the article "Diesel Exhaust Particles Activate the Matrix-Metalloproteinase -1 Gene in Human Bronchial Epithelia in a β-Arrestin Dependent Manner via Activation of RAS" by Li et al. [ Environ Health Perspect 117:400–409 (2009)], the competing financial interest declaration was incorrect.
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Finally, it has also been proposed that polymeric particles can activate the NALP3 inflammasome for the activation of caspase-1 and secretion of IL1 β.
Recent studies have suggested that oxidative stress may be a component of the mechanism by which particles activate cytokine production in cells such as macrophages and epithelial cells.
Despite some cell-based studies which have found that PM causes expression of NF-κB-related genes and oxidant-dependent activation of NF-κB in vitro[ 25], and that air pollution particles activate NF-κB on contact with airway epithelial cell surfaces in a rodent tracheal explant model [ 26], in vivo data are lacking.
Negative (but not positive) electrostatic charge on respired particles can activate the inflammatory vanilloid receptors and acid sensitive ions channels in human respiratory epithelial cells [16].
Furthermore, it is known that GEM particles can activate the maturation of the dendritic cells and macrophages in vitro (32).
Since tetherin restricts the release of a variety of mammalian viruses, we then sought to determine whether other tetherin-sensitive viral particles could activate the NFκB reporter.
These results suggest that GMA particles activate MMPs by protease-substrate interactions to promote EMT and mesenchymal morphogenesis of ESC aggregates in an MMP-dependent manner.
These particles activate an electroless reaction induced by a reducer, hydrazine or hydroxide, which gives rise to deposition of a film with ZnO and ZnSe composition.
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