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We examined the nanoparticles ability to concentrate a dilute PDGF sample, at a concentration below the detection threshold of the ELISA, to determine if the concentration of PDGF could be increased by particle sequestration, rendering the PDGF measurable by the ELISA.
Exposure of HMMs to increasing concentrations of NANC led to increasing particle sequestration by the HMMs (Fig. 5A C).
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We propose SCC formation may be a protective mechanism, an attempt to 'shield' surrounding cells and tissues from damage by rapid sequestration of particle agglomerates/aggregates.
We propose its formation may be a protective mechanism, an attempt to 'shield' themselves and surrounding cells and tissues from damage by rapid sequestration of particle agglomerates or aggregates.
Detecting nanomaterials in the environment is a demanding task, not only because of the extremely small size of the particles and their potential sequestration and agglomeration, but also because of their unique physical and chemical characteristics.
As shown in Fig. 10, trypsin rapidly degraded each class of chemokines in the absence of the sequestration by particles (Fig. 10, Lanes 2, 5, 8).
This approach was designed to minimize non-specific sequestration of particles in the highly fenestrated matrix during the biopanning procedure.
This sequestration requires both particle retention (within the granular sorptive filters) as well as maintained contact time between particles for sorption processes to proceed.
Supposed sequestration of viral particle in the proximity of TLR9 could result in less efficient sensing of HCV RNA by distal TLR7, without affecting TLR7 function, as shown by responses to resiquimod.
We propose that the formation of the SCC is a protective mechanism, 'shielding' surrounding cells and tissues from damage by rapid sequestration of large particle agglomerates.
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