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We thank the study participants and members of the research teams of the participating studies for their assistance and dedication.
Further information on participating studies and ethnic distribution are available in the FAQ of the ExAC database (http://ExAC.broadinstitute.org/faq).org/faq
To overcome these challenges, we propose to perform gene-level tests for rare variants by combining the results of single-variant analysis (i.e., p values of association tests and effect estimates) from participating studies.
Regarding the statistically significant decrease of the gonial angle, although it is in accordance with the four participating studies providing the corresponding treated groups [9] [11],[16], in the study of Altuğ et al. [16], a much further reduction was observed than in the others, standing as an outlier.
This simple strategy is possible because of an insight that multivariate statistics can be recovered from single-variant statistics, together with the correlation matrix of the single-variant test statistics, which can be estimated from one of the participating studies or from a publicly available database.
The study was approved by the Institutional Review Boards of the participating studies.
They coordinate activities and liaise with other participating studies.
OC use was similar across the three participating studies.
Participating studies in Stage 2 are described in Table 1.
Table 1 describes the participating studies and methods of patient ascertainment and histological review.
RCC recruited the participating studies, led the protocol design discussions, and drafted the protocol.
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