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Indeed, there is strong evidence for ROS and RNS participating in the pathogenesis of T1DM while only the participation of ROS can be described as a mechanism of β-cell dysfunction in T2DM [5], [6], [6].
An analogous scenario may hold for estrogen deprivation, perhaps participating in the pathogenesis of post-menopausal osteoporosis [ 71].
Resistin is also known as an adipose tissue-specific secretory factor, participating in the pathogenesis of insulin resistance, adipogenesis and inflammation in mice [ 27, 28].
Subsequent inflammatory and immune responses can trigger the complement cascade and enhance ROS generation participating in the pathogenesis of adverse ventricular remodeling [ 4, 9].
The causes of AD and AMD are likely multi-factorial with several factors such as diet, environment, and genetic susceptibility participating in the pathogenesis of these diseases.
On the contrary, CTGF was taken as a tumor suppressor participating in the pathogenesis of lung cancer, ovarian cancer, and oral squamous cell cancer and so on.
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Peritoneal fluid (PF) inflammatory factors may participate in the pathogenesis of endometriosis.
We therefore examined whether MCV might participate in the pathogenesis of prostate cancer.
Staphylococcus aureus enterotoxin B (SEB) might participate in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP).
Recently, CxHCs have been associated to denervation-induced skeletal muscle atrophy (1), and may also participate in the pathogenesis of corticoids induced muscle atrophy.
This suggests that host-related factors, in addition to an inhaled antigen in cigarette smoke, participate in the pathogenesis of PLCH [5, 6].
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