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Mitochondria play a major role in life and death of cells, ensuring most of the cellular ATP synthesis through oxidative phosphorylations (OXPHOS) and participating in the induction of apoptosis ((Regula et al, 2003) for review).
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Gonadal hormones participate in the induction of behaviour necessary for the union of sperm and eggs; this includes migratory phenomena, heat (estrus) in mammals, courtship, territorial defense, mating, and care of eggs or young.
Defects in mitochondrial function have been shown to participate in the induction of cell death in cancer cells.
The expression of Raldh1 in the developing pancreatic epithelium (Fig. 1a c) suggests that the epithelial cells themselves synthesize retinoids that participate in the induction of Ins+ cells.
Thus, suboptimal TCR stimulation in combination with an inhibition of PI3K/Akt signaling might result in FoxO3a accumulation in the nucleus of iTregs and participate in the induction of Foxp3 expression [54], [55].
Since full function of major histocompatibility complex needs both the invariant chain and variant chain, the PPIs among DQA1, DQB1 and CD74 may participate in the induction of hepatitis C and the development and progression from hepatitis C to HCC.
Taken together, it implies that PPIs among COL1A1, COL1A2, VWF and LUM may participate in the induction of cirrhosis and play roles in the progression from cirrhosis to HCC.
Following influenza A virus (IAV) infection, respiratory dendritic cells (rDC) mature, upregulate costimulatory molecules, and migrate to the regional lymph nodes (LN) where they participate in the induction of virus-specific CD8 T cell responses [1], [2], [3].
It has been suggested that TLR4 leads to signal activation via downstream signaling factors such as MyD88, IRAKs and TRAF6, and that a TRAF6-dependent pathway engages MAPK and IKK, resulting in activation of transcription factors that participate in the induction of proinflammatory cytokines such as NF-κB and AP-1 [34] [34].
SG participated in the induction of the experimental Diabetes.
TLR2, TLR7 and TLR8 may participate in the induction of cytokines/chemokines in EV71-infected MDMs.
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