Thus, it might be that, due to as yet undefined mechanisms, tissues that participate to the development of ventral midline structures and their abnormalities are particularly sensitive towards MID1 dysfunction.
Among the genes involved in nervous system development and function and organ development, BMI1 (Polycomb ring finger oncogene), GBX2 (Gastrulation brain homeobox 2), OTX2 (Orthodenticle homeobox 2), SOX4 (SRY-box 4), ZNF423 (Zinc finger protein 423) and NKX6-1 (NK6 homeobox 1) participate to the development of nervous organs or cells, migration of neurons or neurogenesis.
LB participated to the development of the protocol and wrote the manuscript.
Indeed, inflammation of the vascular wall is for example disturbing the uptake and release equilibrium of lipids by macrophages, making them become lipid-loaded foam cells by mechanisms involving oxidized LDL, and thus participate to the development of atherosclerosis [ 56].
Also, inflamed microglia (the resident brain macrophages) have been shown to produce enhanced quantities of quinolinic acid, a metabolite of the tryptophan-derived kynurenin, which can become toxic to the brain and could participate to the development of various neurodegenerative processes among which Alzheimer's and Parkinson's diseases [ 52, 60].
At the intracranial level, four embryonic arteries (trigeminal, otic, hypoglossal and proatlantal) participate to the VB development: once completed, these vessels gradually regress, but in some cases they may persist [7].
TR, LK, EJ and AM participated equally to the development and preparation of the manuscript.
NASA is beginning to look to DIY communities to participate in the development of "SmallSats," which use available components like smartphones and Legos, making it possible to build satellites for close to $1,000.
All disciplines involved in NHL care were asked to provide delegates to participate in the development of the indicator set.
