- In addition, it has been reported that the three ESCRT (Endosomal sorting complex required for transport) complexes, I III, which were originally associated with the sorting of ubiquitinated membrane proteins into multivesicular bodies, - participate in the fusion of autophagosomes with lysosomes by mechanisms that are still unknown.
Usually it is in the fusion of the two from which the best ideas are born.
This effect could be due to the oxidation of lipids[23] and/or proteins[24] that participate in the fusion and subsequent penetration of the oocyte by sperm.
Even more strikingly, epithelial cells lack constitutive expression of HLA class II, which renders gp42 incapable of participating in the fusion process.
The occurrence of gene fusions suggests that the two original genes that participated in the fusion are functionally linked, i.e. their gene products interact either as part of a multi-subunit protein complex, or in a metabolic pathway.
Syntaxin-6 interacts directly with the C-terminal-binding site of EEA1 which overlaps with that of Rab5 and participates in the in vitro fusion of EEs [ 64, 70].
On the other hand, our attempts to determine which Qa-SNARE(s) participates in fusion of recycling vesicles have so far been unsuccessful, since SNAP23/25 and VAMP2 can form complexes with various syntaxins, including syntaxin 2, syntaxin 3 and syntaxin 4 (Hong, 2005; Hong and Lev, 2014).
Based on present and previous data, we propose a model in which GMAP210 would participate in homotypic fusion of cis-cisternae by anchoring the surface of cisternae via its C-terminus and projecting its distal N-terminus to bind the rims or to stabilise tubular structures connecting neighbouring cis-cisternae.
Data presented here support a model in which GMAP210 would participate in homotypic fusion of cis-cisternae by anchoring the surface of cisternae via its C-terminus and projecting its distal N-terminus to bind the rims or to stabilise tubular structures connecting neighbouring cis-cisternae.
Our data support a model in which GMAP210 would participate in homotypic fusion of cis-cisternae by anchoring the surface of cisternae via its C-terminus and projecting its distal N-terminus to bind the rims or to stabilise tubular structures connecting neighbouring cis-cisternae.
