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ALPase participates in the differentiation of osteoblasts and provides phosphate for hydroxyapatite mineral formation.
STAT1 also participates in the differentiation of B cells [ 4, 5] and T cells [ 6, 7].
The homologue of Wo in Arabidopsis, i.e., PROTODERMAL FACTOR2, participates in the differentiation of shoot epidermal cell but not in trichome initiation [ 22].
To determine whether BMP signaling participates in the differentiation of Müller glia, we monitored the phosphorylation of Smad1/5/8 by immunofluorescence and western blots in the first two postnatal weeks.
Considering Pdx-1 is required for β-cell generation and maturation at embryonic period, we further assume that Foxo1 probably participates in the differentiation of ES cells into functional INS+ cells.
Because lactation participates in the differentiation of mammary epithelium in its terminal phase (Russo and Russo, 1994b; Russo et al, 2001, 2008), deficient breastfeeding of the first child might leave the breast cells susceptible to carcinogenic influences.
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However, it is probable that some of these proteins participate in the differentiation of tracheary elements, such as AtXTH32 which was only identified at 11 days.
Although p38, JUK and MEK/ERK signaling cascades participated in the differentiation of CML, only the MEK/ERK signal pathway has an essential role in MK differentiation.
The periosteum, a fibrous tissue which covers the bone surface, is known to participate in the differentiation of chondrocytes and osteoblasts in fracture healing [ 25].
Multiple signaling pathways have been demonstrated to participate in the differentiation of an osteoblast progenitor to a committed osteoblast [ 30, 31].
Data show that plant bZIP proteins participate in the differentiation of many organs and tissues, embryogenesis, seed maturation, floral transition and initiation, and vascular development.
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