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Thus, in the case that chemotaxis signaling is suppressed in the presence of an inhibitor, it means that the blocked molecule participates downstream the increase in the cyclic nucleotide.
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The observed punctate pattern has been seen for other LOXs and also in genes that participate downstream of the LOX pathway (HPL, AOS, AOC).
These results suggest that at least some of the E spl) complex members might also participate downstream of Notch to promote cell proliferation in the hinge.
To extend the regulatory pathways in which the miRNAs participate downstream, we predicted miRNA targets, using TargetScanHuman version 5.1 [ 15] and PicTar [ 46].
The upregulation and proximity of these genes suggest that Q7CU96 may participate downstream of A9CG74 in a metabolic pathway for m-galactarate degradation.
Mutational activation of RAS proteins is associated with the occurrence of almost 30% of all human tumors, but due to off-target and severe side effects clinical trials based on small molecule inhibitors targeting participating downstream kinases including Raf, MEK and ERK1/2 have so far not been very successful.
With its structural plasticity, its ability to bind ligands, and its NOD activity, THB1 may participate in downstream regulatory processes.
Therefore, it was probable that some 5′-monophosphate 22G-RNAs were present and participated in downstream regulation of the 21U-RNA-mediated pathway.
The hairpins are designed with structures that initially keep key sequence domains, called toeholds, inaccessible; each hairpin can then be opened by a specific initiator strand, allowing the newly accessible toeholds to participate in downstream reactions.
Syk activation participates in the downstream signaling of IgAN and may serve as a therapeutic target.
It participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation.
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