As cathepsin D can also mediate caspase 8 cleavage, which in turn can participate to the processing of Bid, we found that pepstatin A also reduced caspase 8 cleavage.
The work was funded by the Seventh Framework Programme of the European Commission (grant number HEALTH-F2-2008-201626). MT drafted the paper, performed statistical analysis and data processing, and participated to the data interpretation.
The obtained data demonstrated that, in NB4 cells treated with ATRA, Vav1 is involved in determining the nuclear amount of proteins involved in molecular complexes with DNA and may participate to RNA processing by carrying in the nucleus molecules involved in modulating mRNA production and stability, like hnRNPs and SR proteins.
GS elaborated stimuli, participated to EEG acquisition and post-processing, statistical analysis, redaction of the manuscript and created figures.
In addition to coilin, pearls contain WRAP53 (WDR79/TCAB), scaRNAs and U3 snoRNA and are thought to participate in the processing of RNA pol III transcripts.
The proteins are thought to participate in the processing mRNA precursors [ 33], and they can influence splice site selection and promote exon skipping in vitro [ 57- 59].
In addition, the network of interneurons located in the larval antennal lobe (Das et al., 2013) is expected to participate in the processing of olfactory information arising from the OSNs (Asahina et al., 2009; Larkin et al., 2010).
P2X7R has been reported to participate in the processing and release of cytokines, such as interleukin-1 β (IL-1 β), and in the initiation of cell death via both apoptotic and necrotic pathways.
Our study suggests that there are multiple Argonaute/PIWI as well as double-stranded RNA-binding proteins and exportins which, by evolutionary associations, are hypothesized to participate in the processing of additional classes of ncRNAs and might warrant further experimental investigation.
EB and AR participated in the processing and analyses of DTCs and EB contributed to writing of the manuscript.
