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VD conceived the study, participated to its implementation and in the analysis.
JPL and MB conceived and supported the study at the hospital level and participated to its design and coordination.
FM, JB and G. Tornese conceived the study, participated to its design and coordination, and wrote the first draft of the manuscript.
C Rovery participated to the conception of the study, participated to its coordination, drafted the paper and took in charge the patient in hospitalization.
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They indeed participate to its formation and continuous enrichment, and they also contribute to its valorization, through notably the commercialization of technologies developed within innovation networks.
Beyond field-based surveys included in its construction, the model is carrying a vision for change of the health system in all its dimensions and likely to be adopted by all the actors who share the standards and participate to its dynamic.
CDM conceived the study, participated to in its design and coordination and helped to draft the manuscript.
SI participated to conceive the study and its design and helped to draft the manuscript.
EM participated to conceive the study and its design and helped to draft the manuscript.
In fact, when cells do not adhere to the matrix, integrin αvβ3 interacts with MMP-2 and so participates to its activation [ 29].
While additional analyses are needed to investigate whether this hypermethylation is a by-product of gene expression or participates to its regulation, even to a low extent, our study provides the first detailed DNA methylation characterization of VRN-A1.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com