When cells are fed a growth substrate with certain carbon positions labeled with 13C, the distribution of this label in the intracellular metabolites can be calculated based on the known biochemistry of the participating pathways.
Some potential candidates for the participating pathways were uncovered in our genetic screen for genes that modulate the Aβ42 induced rough eye phenotype.
Due to the large size of this network, and to aid visual exploration, we only include pathway interactions for which at least one of the participating pathways is significantly enriched (p < 0.05) with differentially expressed genes.
In particular we hoped to identify proteins that participated in pathways connecting cell death with microtubule drug challenge.
SHN participated in pathway analysis using Pathway Studio tool and performed promoter module analysis using MatInspector.
The pathway scheme generates a list of genes that participate in pathways relevant to the synthesis or degradation of the metabolite.
Some of the genes in module M6 participate in pathways enriched in module M1, including TLR4 ('Toll-like receptor signaling pathway'), PPARG and NFAM1 ('PPAR signaling pathway').
The Rac family is one of the most important regulators of signal transduction in plants, participating in pathways that influence growth and development, and the adaptation of plants to various environmental situations (Berken 2006).
Another major inflammatory signaler, the Wingless family (Wnt) proteins, participate in pathways controlling differentiation, inflammation, and tumorigenesis [29].
We compiled gene modules from either homologs or functionally related sets of genes that co-participate in pathways, protein-protein interactions, and protein complexes (Figure 1).
Other human RecQ helicases, particularly WRN and BLM, have been proposed to participate in pathways which help cells to deal with replicational stress or repair DNA damage [2].
